Traits

Traits linked to DSG4

desmoglein 4

The Human Phenotype Ontology links 22 traits to DSG4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Brittle hair	Always
Itching	Always
Sparse hair	Always
Abnormality of the nail	Very often (80–99%)
Fine hair	Very often (80–99%)
Follicular hyperkeratosis	Very often (80–99%)
Hair loss	Very often (80–99%)
Patchy baldness	Very often (80–99%)
Slow-growing hair	Very often (80–99%)
Sparse body hair	Very often (80–99%)
Flattened and twisted hair	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal eyelashes	Very often (80–99%)
Abnormality of the eyebrow	Very often (80–99%)
Sparse eyebrow	Very often (80–99%)
Sparse eyelashes	Very often (80–99%)
Sparse scalp hair	Very often (80–99%)
Abnormal dentition	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Cognitive impairment	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Schizophrenia	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Redness of skin or mucous membrane	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DSG4 and how often each is seen. Find out more at hpo.jax.org.

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