Skip to content
Use your HSA or FSA funds

Gene

CYBRD1

cytochrome b reductase 1

Summary

Cytogenetic location
2q31.1
Coordinates
Chromosome 2: 171,522,474–171,558,129 (GRCh38)
Exons
4 exons across 35.7 kb
Protein
286 amino acids
Also known as
DCYTB, FLJ23462, FRRS3, CYB561A2
MANE Select transcript
ENST00000321348.9NM_024843.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hemochromatosis

    • Hereditary Hemochromatosis

      An inherited metabolic disorder characterized by iron accumulation in the tissues.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Phlebotomy, iron chelation, iron restriction diet, family screening

How CYBRD1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 2, with a bracket where CYBRD1 sits. CYBRD1 and 7 genes near it on chromosome 2, from 171,040,302 to 172,040,301.Chromosome 22q31.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3171.2 Mb171.4 Mb171.6 Mb171.8 Mb172 MbTLK1: 170,990,823–171,231,314, reverse strandTLK1METTL8: 171,315,746–171,434,802, reverse strandMETTL8DCAF17: 171,434,217–171,491,318, forward strandDCAF17CYBRD1: 171,522,474–171,558,129, forward strandCYBRD1DYNC1I2: 171,687,409–171,750,179, forward strandDYNC1I2SLC25A12: 171,781,168–171,999,859, reverse strandSLC25A12HAT1: 171,922,404–171,986,773, forward strandHAT1METAP1D: 171,999,935–172,083,989, forward strandMETAP1DDiagram of CYBRD1: 4 exons on the forward strand of chromosome 2Exon 1: 171,522,474–171,522,738, 265 basesExon 2: 171,541,585–171,541,793, 209 basesExon 3: 171,553,346–171,553,500, 155 basesExon 4: 171,554,524–171,558,129, 3,606 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 35.7 kb; 861 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CYBRD1 gene: cytochrome b reductase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/cybrd1

Vancouver

Dante Labs. CYBRD1 gene: cytochrome b reductase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cybrd1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test