Traits

Traits linked to CTSF

cathepsin F

The Human Phenotype Ontology links 22 traits to CTSF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Dementia	Always
Diffuse cerebral atrophy	Always
Mental deterioration	Always
Ataxia	Often (30–79%)
Decrease in size of the outer layer of the brain due to loss of brain cells	Often (30–79%)
Difficulty articulating speech	Often (30–79%)
Grand mal seizures	Often (30–79%)
Tremor	Often (30–79%)
Can't control feelings	Sometimes (5–29%)
Confusion	Sometimes (5–29%)
Degeneration of cerebellum	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Inability to coordinate movements when walking	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Loss of brain cells	Sometimes (5–29%)
Seizure affecting one half of brain	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)
Abnormality of extrapyramidal motor function	Not recorded
Babinski sign	Not recorded
Epilepsy	Not recorded
Jerking	Not recorded
Primitive reflex	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CTSF and how often each is seen. Find out more at hpo.jax.org.

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