Traits

Traits linked to CCDC91

coiled-coil domain containing 91

The Human Phenotype Ontology links 12 traits to CCDC91, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Fragmented elastic fibers in the dermis	Very often (80–99%)
Hyperkeratotic papule	Very often (80–99%)
Thickening of upper layer of skin	Very often (80–99%)
Hypergranulosis	Often (30–79%)
Orthokeratosis	Often (30–79%)
Yellow papule	Often (30–79%)
Piezogenic pedal papules	Sometimes (5–29%)
Skin plaque	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Thickening of the outer layer of the skin of the palms and soles	Very often (80–99%)
Excessive sweating of hands	Sometimes (5–29%)
Abnormality of the lower limb	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Granulomatosis	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CCDC91 and how often each is seen. Find out more at hpo.jax.org.

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