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Risk score · Heart & circulation

Coronary Artery Disease Polygenic Risk Score

Coronary artery disease is the narrowing of the arteries that supply the heart, and the main cause of heart attacks. This score uses about 40,000 variants.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Coronary artery disease

Genetic variants

40,079

Method

lassosum

Built from studies of

European 75%, South Asian 14%, East Asian 6%, Hispanic or Latin American 2%, African 2%, Greater Middle Eastern 1%

Developed in

Multi-ancestry 100%

Evaluated in

Multi-ancestry 83%, European 17%

Published

Elliott J et al. (2020). Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease. JAMA.

The score in the PGS Catalog →

References

  1. Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, 2015. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet

Other heart & circulation risk scores

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

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