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Risk score · Heart & circulation

Lipoprotein(a) Polygenic Score

Lipoprotein(a) is a cholesterol-carrying particle whose level is set largely by genetics and barely changes with lifestyle. High levels raise the risk of heart disease.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Lipoprotein A

Genetic variants

43

Method

Genome-wide significant variants

Built from studies of

European 100%

Evaluated in

European 73%, African 13%, East Asian 7%, South Asian 7%

Published

Trinder M et al. (2020). Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease. JAMA Cardiol.

The score in the PGS Catalog →

References

  1. Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, 2018. Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis. JAMA Cardiol

Other heart & circulation risk scores

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