Risk score · Heart & circulation
Stroke Polygenic Risk Score
A stroke happens when blood supply to part of the brain is cut off or a vessel bleeds. Blood pressure, smoking and activity matter most, and genetics adds to them.
A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.
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How the score works
A polygenic score for Stroke
Genetic variants
- 90
Method
- Clumping and Thresholding (C+T)
Built from studies of
- European 100%
Evaluated in
- European 100%
Published
Rutten-Jacobs LC et al. (2018). Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants. BMJ.
References
- Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, 2018. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet
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