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Risk score · Heart & circulation

Blood Clot (VTE) Polygenic Risk Score

Venous thromboembolism covers blood clots in the deep veins (DVT) and lungs (pulmonary embolism). Surgery, long travel, pregnancy and some medicines raise risk.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Venous thromboembolism

Genetic variants

297

Method

Pruning + Clumping

Built from studies of

European 89%, African 8%, Hispanic or Latin American 3%

Evaluated in

European 80%, Multi-ancestry 20%

Published

Klarin D et al. (2019). Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet.

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