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Risk score · Heart & circulation

Atrial Fibrillation Polygenic Risk Score

Atrial fibrillation is the most common heart rhythm disorder. It becomes more common with age and raises the risk of stroke.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Atrial fibrillation

Genetic variants

1,168

Method

Pruning and Thresholding (P+T)

Built from studies of

European 90%, African 4%, East Asian 3%, Hispanic or Latin American 3%

Developed in

European 100%

Evaluated in

Multi-ancestry 67%, European 17%, MAO 17%

Published

Weng LC et al. (2017). Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation. Circulation.

The score in the PGS Catalog →

References

  1. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, 2017. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet

Other heart & circulation risk scores

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

From $449

Free shipping · Results in 6–8 weeks

Get my Genome Test