{
  "url": "https://dantelabs.com/traits/subvalvular-aortic-stenosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "subvalvular-aortic-stenosis",
    "id": "HP:0001682",
    "name": "Narrowing of blood vessel below aortic heart valve",
    "label": "Subvalvular aortic stenosis",
    "definition": "A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve.",
    "synonyms": [
      "Subaortic stenosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-left-ventricular-outflow-tract-morphology",
        "name": "Abnormal left ventricular outflow tract morphology",
        "url": "https://dantelabs.com/traits/abnormal-left-ventricular-outflow-tract-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "muscular-subvalvular-aortic-stenosis",
        "name": "Muscular subvalvular aortic stenosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/muscular-subvalvular-aortic-stenosis"
      }
    ],
    "genes": [
      {
        "slug": "wdpcp",
        "symbol": "WDPCP",
        "hgnc": "HGNC:28027",
        "name": "WD repeat containing planar cell polarity effector",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdpcp"
      },
      {
        "slug": "cep57",
        "symbol": "CEP57",
        "hgnc": "HGNC:30794",
        "name": "centrosomal protein 57",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cep57"
      },
      {
        "slug": "tab2",
        "symbol": "TAB2",
        "hgnc": "HGNC:17075",
        "name": "TGF-beta activated kinase 1 (MAP3K7) binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tab2"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "hgnc": "HGNC:12874",
        "name": "Zic family zinc finger 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic3"
      },
      {
        "slug": "adamts19",
        "symbol": "ADAMTS19",
        "hgnc": "HGNC:17111",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts19"
      },
      {
        "slug": "bub1",
        "symbol": "BUB1",
        "hgnc": "HGNC:1148",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1"
      },
      {
        "slug": "bub1b",
        "symbol": "BUB1B",
        "hgnc": "HGNC:1149",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1b"
      },
      {
        "slug": "bub3",
        "symbol": "BUB3",
        "hgnc": "HGNC:1151",
        "name": "BUB3 mitotic checkpoint protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub3"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "hgnc": "HGNC:9644",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn11"
      },
      {
        "slug": "syt2",
        "symbol": "SYT2",
        "hgnc": "HGNC:11510",
        "name": "synaptotagmin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syt2"
      },
      {
        "slug": "trip13",
        "symbol": "TRIP13",
        "hgnc": "HGNC:12307",
        "name": "thyroid hormone receptor interactor 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip13"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "cav3",
        "symbol": "CAV3",
        "hgnc": "HGNC:1529",
        "name": "caveolin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav3"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "ifih1",
        "symbol": "IFIH1",
        "hgnc": "HGNC:18873",
        "name": "interferon induced with helicase C domain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifih1"
      },
      {
        "slug": "myh6",
        "symbol": "MYH6",
        "hgnc": "HGNC:7576",
        "name": "myosin heavy chain 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh6"
      },
      {
        "slug": "myh7",
        "symbol": "MYH7",
        "hgnc": "HGNC:7577",
        "name": "myosin heavy chain 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh7"
      }
    ]
  }
}