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Trait

Sideroblastic anemia

Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).

HPO HP:0001924

Summary

Also called
Hypersideremic anaemia, Hypersideremic anemia, Sideroblastic anaemia
Body system
Abnormality of blood and blood-forming tissues

12 genes linked to Sideroblastic anemia

Changes in these genes cause rare conditions in which Sideroblastic anemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ABCB7ATP binding cassette subfamily B member 7AlwaysIn 2 conditions
ALAS25'-aminolevulinate synthase 2AlwaysIn 1 condition
PUS1pseudouridine synthase 1AlwaysIn 1 condition
TRNT1tRNA nucleotidyl transferase 1AlwaysIn 1 condition
YARS2tyrosyl-tRNA synthetase 2AlwaysIn 1 condition
STEAP3STEAP3 metalloreductaseOften (30–79%)In 1 condition
HSPA9heat shock protein family A (Hsp70) member 9Not recordedIn 1 condition
ISCUiron-sulfur cluster assembly enzymeNot recordedIn 1 condition
LARS2leucyl-tRNA synthetase 2, mitochondrialNot recordedIn 1 condition
SLC19A2solute carrier family 19 member 2Not recordedIn 1 condition
SLC25A38solute carrier family 25 member 38Not recordedIn 1 condition
WFS1wolframin ER transmembrane glycoproteinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Anemia of inadequate production

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

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