{
  "url": "https://dantelabs.com/traits/palmoplantar-hyperhidrosis",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "palmoplantar-hyperhidrosis",
    "id": "HP:0007410",
    "name": "Excessive sweating of palms and soles",
    "label": "Palmoplantar hyperhidrosis",
    "definition": "An abnormally increased perspiration on palms and soles.",
    "synonyms": [
      "Hyperhidrosis of palms and soles"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-plantar-skin-of-foot",
        "name": "Abnormality of the plantar skin of foot",
        "url": "https://dantelabs.com/traits/abnormality-of-the-plantar-skin-of-foot"
      },
      {
        "slug": "palmar-hyperhidrosis",
        "name": "Excessive sweating of hands",
        "url": "https://dantelabs.com/traits/palmar-hyperhidrosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "perp",
        "symbol": "PERP",
        "hgnc": "HGNC:17637",
        "name": "p53 apoptosis effector related to PMP22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/perp"
      },
      {
        "slug": "plaa",
        "symbol": "PLAA",
        "hgnc": "HGNC:9043",
        "name": "phospholipase A2 activating protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plaa"
      },
      {
        "slug": "serpinb7",
        "symbol": "SERPINB7",
        "hgnc": "HGNC:13902",
        "name": "serpin family B member 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinb7"
      },
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      },
      {
        "slug": "cdsn",
        "symbol": "CDSN",
        "hgnc": "HGNC:1802",
        "name": "corneodesmosin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdsn"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt17",
        "symbol": "KRT17",
        "hgnc": "HGNC:6427",
        "name": "keratin 17",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt17"
      },
      {
        "slug": "krt6a",
        "symbol": "KRT6A",
        "hgnc": "HGNC:6443",
        "name": "keratin 6A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt6a"
      },
      {
        "slug": "krt6b",
        "symbol": "KRT6B",
        "hgnc": "HGNC:6444",
        "name": "keratin 6B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt6b"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "ctsb",
        "symbol": "CTSB",
        "hgnc": "HGNC:2527",
        "name": "cathepsin B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsb"
      },
      {
        "slug": "rspo1",
        "symbol": "RSPO1",
        "hgnc": "HGNC:21679",
        "name": "R-spondin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo1"
      }
    ]
  }
}