{
  "url": "https://dantelabs.com/traits/onychogryphosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "onychogryphosis",
    "id": "HP:0001805",
    "name": "Thick nail",
    "label": "Onychogryphosis",
    "definition": "Onychogryphosis is a disorder of nail plate growth that is clinically characterized by an opaque, yellow-brown thickening of the nail plate with associated gross hyperkeratosis, elongation, and increased curvature.",
    "synonyms": [
      "Thickened nails",
      "Dystrophic thickened nails",
      "Onychogryposis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nail-morphology",
        "name": "Abnormality of the nail",
        "url": "https://dantelabs.com/traits/abnormal-nail-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "onychogryphosis-of-fingernail",
        "name": "Overgrowth and curving of fingernail",
        "genes": 9,
        "url": "https://dantelabs.com/traits/onychogryphosis-of-fingernail"
      },
      {
        "slug": "onychogryphosis-of-toenails",
        "name": "Overgrowth and curving of toenails",
        "genes": 7,
        "url": "https://dantelabs.com/traits/onychogryphosis-of-toenails"
      },
      {
        "slug": "onychauxis",
        "name": "Onychauxis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/onychauxis"
      }
    ],
    "genes": [
      {
        "slug": "adam17",
        "symbol": "ADAM17",
        "hgnc": "HGNC:195",
        "name": "ADAM metallopeptidase domain 17",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/adam17"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "krt83",
        "symbol": "KRT83",
        "hgnc": "HGNC:6460",
        "name": "keratin 83",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt83"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "fzd6",
        "symbol": "FZD6",
        "hgnc": "HGNC:4044",
        "name": "frizzled class receptor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzd6"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "loricrin",
        "symbol": "LORICRIN",
        "hgnc": "HGNC:6663",
        "name": "loricrin cornified envelope precursor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/loricrin"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt6a",
        "symbol": "KRT6A",
        "hgnc": "HGNC:6443",
        "name": "keratin 6A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt6a"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      }
    ]
  }
}