Polygen riskpoäng för lungcancer

En polygen poäng för Lung cancer

Genetiska varianter

128

Metod

Clumped lung cancer loci (35 SNP score) combined with LASSO penalized regression (93 SNP score)

Baserad på studier av

Europeisk 100%

Utvecklad i

Europeisk 100%

Utvärderad i

Europeisk 92%, Afrikansk 8%

Referenser

1. Poirier JG, Brennan P, McKay JD, Spitz MR, Bickeböller H, Risch A, 2015. Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer. Genet Epidemiol
2. Weissfeld JL, Lin Y, Lin HM, Kurland BF, Wilson DO, Fuhrman CR, 2015. Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions. J Thorac Oncol
3. Brenner DR, Amos CI, Brhane Y, Timofeeva MN, Caporaso N, Wang Y, 2015. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis
4. Kachuri L, Amos CI, McKay JD, Johansson M, Vineis P, Bueno-de-Mesquita HB, 2016. Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. Carcinogenesis
5. McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, 2017. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet

Andra cancer risk scores

• Basalcellscancer
• Bukspottkörtelcancer
• Melanom
• Prostatacancer
• Tjocktarmscancer
• Äggstockscancer