Skip to content
Use your HSA or FSA funds

Risk score · Cancer

Lung Cancer Polygenic Risk Score

Smoking is by far the largest risk factor for lung cancer, but inherited variants also play a part, in smokers and non-smokers alike.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

Included in Premium and Premium + AI

Premium adds $99 per kit for the first year.

Order with Premium

A polygenic score for Lung cancer

Genetic variants

128

Method

Clumped lung cancer loci (35 SNP score) combined with LASSO penalized regression (93 SNP score)

Built from studies of

European 100%

Developed in

European 100%

Evaluated in

European 92%, African 8%

Published

Hung RJ et al. (2021). Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model. Cancer Res.

The score in the PGS Catalog →

References

  1. Poirier JG, Brennan P, McKay JD, Spitz MR, Bickeböller H, Risch A, 2015. Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer. Genet Epidemiol
  2. Weissfeld JL, Lin Y, Lin HM, Kurland BF, Wilson DO, Fuhrman CR, 2015. Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions. J Thorac Oncol
  3. Brenner DR, Amos CI, Brhane Y, Timofeeva MN, Caporaso N, Wang Y, 2015. Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis
  4. Kachuri L, Amos CI, McKay JD, Johansson M, Vineis P, Bueno-de-Mesquita HB, 2016. Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. Carcinogenesis
  5. McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, 2017. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet

Other cancer risk scores

All conditions →

One test. A lifetime of answers.

One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

From $449

Free shipping · Results in 6–8 weeks

Premium adds $99 per kit for the first year.

Order with Premium