Traits

Traits linked to TEK

TEK receptor tyrosine kinase

The Human Phenotype Ontology links 35 traits to TEK, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Glaucoma	Very often (80–99%)
Abnormal Descemet membrane morphology	Often (30–79%)
Corneal opacity	Often (30–79%)
Deep anterior chamber	Often (30–79%)
Enlarged cornea	Often (30–79%)
Enlarged eyeball	Often (30–79%)
Extreme sensitivity of the eyes to light	Often (30–79%)
High eye pressure	Often (30–79%)
Increased tears	Often (30–79%)
Iris degeneration	Often (30–79%)
Reduced anterior scleral thickness	Often (30–79%)
Anisometropia	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Decreased clarity of vision	Sometimes (5–29%)
Iridodonesis	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)
Visual loss	Sometimes (5–29%)
Increased cup-to-disc ratio	Not recorded
Primary congenital glaucoma	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Arteriovenous malformation	Very often (80–99%)
Collection of dilated blood vessels that forms mass	Very often (80–99%)
Visceral angiomatosis	Very often (80–99%)
Abnormality of the vasculature	Often (30–79%)
Venous malformation	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Prolonged bleeding time	Very often (80–99%)
Abnormality of coagulation	Often (30–79%)
Intestinal bleeding	Often (30–79%)
Microcytic anemia	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Volvulus	Often (30–79%)
Death of digestive organ tissue due to poor blood supply	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Eyelid spasm	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Skin rash	Very often (80–99%)

Abnormality of the integument

Trait	How often it is seen
Firm lump under the skin	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bone pain	Very often (80–99%)

Laboratory abnormality

Trait	How often it is seen
Corneal stromal edema	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TEK and how often each is seen. Find out more at hpo.jax.org.

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