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Gene

SIX4

SIX homeobox 4

Summary

Cytogenetic location
14q23.1
Coordinates
Chromosome 14: 60,709,539–60,724,351 (GRCh38)
Exons
3 exons across 14.8 kb
Protein
781 amino acids
Also known as
AREC3
MANE Select transcript
ENST00000216513.5NM_017420.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SIX4 yet. The test sequences your whole genome, so your data includes it all the same.

How SIX4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 14, with a bracket where SIX4 sits. SIX4 and 8 genes near it on chromosome 14, from 60,216,945 to 61,216,944.Chromosome 1414q23.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3360.4 Mb60.6 Mb60.8 Mb61 Mb61.2 MbPPM1A: 60,245,752–60,299,223, forward strandPPM1AC14orf39: 60,396,469–60,515,543, reverse strandC14orf39SIX6: 60,509,146–60,512,850, forward strandSIX6SIX1: 60,643,421–60,658,259, reverse strandSIX1SIX4: 60,709,539–60,724,351, reverse strandSIX4MNAT1: 60,734,733–60,973,862, forward strandMNAT1TRMT5: 60,971,441–60,981,694, reverse strandTRMT5SLC38A6: 60,981,106–61,114,316, forward strandSLC38A6PRKCH: 61,187,559–61,550,980, forward strandPRKCHDiagram of SIX4: 3 exons on the reverse strand of chromosome 14Exon 3: 60,709,539–60,714,203, 4,665 basesExon 2: 60,719,760–60,720,445, 686 basesExon 1: 60,723,212–60,724,351, 1,140 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.5 kb of the gene's 14.8 kb; 2,346 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). SIX4 gene: SIX homeobox 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/six4

Vancouver

Dante Labs. SIX4 gene: SIX homeobox 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/six4

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