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Gene

QRICH2

glutamine rich 2

Summary

Cytogenetic location
17q25.1
Coordinates
Chromosome 17: 76,274,049–76,308,276 (GRCh38)
Exons
19 exons across 34.2 kb
Protein
1,887 amino acids
Also known as
DKFZP434P0316
MANE Select transcript
ENST00000680821.2NM_001388453.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • 1 GenCC submitter rates it definitive or strong

How QRICH2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where QRICH2 sits. QRICH2 and 36 genes near it on chromosome 17, from 75,791,163 to 76,791,162.Chromosome 1717q25.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.375.8 Mb76 Mb76.2 Mb76.4 Mb76.6 MbUNK: 75,784,799–75,825,799, forward strandUNKUNC13D: 75,827,032–75,845,353, reverse strandUNC13DWBP2: 75,845,699–75,856,507, reverse strandWBP2TRIM47: 75,874,161–75,878,637, reverse strandTRIM65: 75,879,538–75,897,018, reverse strandTRIM65MRPL38: 75,898,642–75,905,097, reverse strandMRPL38: 75,898,645–75,930,129, reverse strandFBF1: 75,908,212–75,941,140, reverse strandFBF1ACOX1: 75,941,507–75,979,459, reverse strandACOX1TEN1: 75,979,212–76,000,587, forward strandTEN1TEN1-CDK3: 75,979,231–76,005,999, forward strandTEN1-CDK3CDK3: 76,000,644–76,005,999, forward strandCDK3EVPL: 76,004,379–76,027,465, reverse strandEVPLSRP68: 76,037,989–76,072,718, reverse strandSRP68ZACN: 76,071,961–76,083,666, forward strandZACNGALR2: 76,074,773–76,077,537, forward strandGALR2EXOC7: 76,080,995–76,121,576, reverse strandEXOC7FOXJ1: 76,136,333–76,141,256, reverse strandFOXJ1RNF157: 76,142,460–76,240,662, reverse strandRNF157UBALD2: 76,265,197–76,271,298, forward strandUBALD2QRICH2: 76,274,049–76,308,276, reverse strandQRICH2PRPSAP1: 76,309,478–76,384,521, reverse strandPRPSAP1SPHK1: 76,376,584–76,387,860, forward strandSPHK1UBE2O: 76,389,456–76,453,226, reverse strandUBE2OAANAT: 76,452,749–76,470,122, forward strandAANATRHBDF2: 76,470,884–76,501,790, reverse strandRHBDF2CYGB: 76,527,356–76,551,175, reverse strandCYGBPRCD: 76,527,586–76,553,578, forward strandPRCD: 76,563,710–76,569,724, reverse strandST6GALNAC2: 76,564,424–76,586,956, reverse strandST6GALNAC2ST6GALNAC1: 76,624,228–76,643,907, reverse strandST6GALNAC1MXRA7: 76,672,551–76,711,091, reverse strandMXRA7JMJD6: 76,712,830–76,726,784, reverse strandJMJD6METTL23: 76,725,981–76,735,416, forward strandMETTL23: 76,732,978–76,738,522, forward strandSRSF2: 76,734,115–76,737,919, reverse strandSRSF2MFSD11: 76,735,865–76,789,874, forward strandDiagram of QRICH2: 19 exons on the reverse strand of chromosome 17Exon 16: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 19: 76,274,049–76,274,260, 212 basesExon 18: 76,275,819–76,275,947, 129 basesExon 17: 76,276,680–76,276,767, 88 basesExon 16: 76,277,163–76,277,310, 148 basesExon 15: 76,277,989–76,278,189, 201 basesExon 14: 76,279,041–76,279,142, 102 basesExon 13: 76,279,363–76,279,428, 66 basesExon 12: 76,280,033–76,280,154, 122 basesExon 11: 76,280,287–76,280,451, 165 basesExon 10: 76,280,654–76,280,728, 75 basesExon 9: 76,280,831–76,280,953, 123 basesExon 8: 76,281,864–76,282,115, 252 basesExon 7: 76,287,192–76,287,306, 115 basesExon 6: 76,287,800–76,287,897, 98 basesExon 5: 76,289,992–76,290,077, 86 basesExon 4: 76,291,015–76,294,021, 3,007 basesExon 3: 76,304,415–76,304,525, 111 basesExon 2: 76,304,882–76,304,941, 60 basesExon 1: 76,307,465–76,308,276, 812 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 34.2 kb; 5,664 of those bases code for the protein.

How a genome test reads QRICH2

6

positions in QRICH2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 34.2 kb of QRICH2, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). QRICH2 gene: glutamine rich 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/qrich2

Vancouver

Dante Labs. QRICH2 gene: glutamine rich 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/qrich2

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