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Gene

PRDM13

PR/SET domain 13

Summary

Cytogenetic location
6q16.2
Coordinates
Chromosome 6: 99,606,833–99,615,562 (GRCh38)
Exons
4 exons across 8.7 kb
Protein
707 amino acids
Inheritance
Autosomal dominant
Also known as
PFM10
MANE Select transcript
ENST00000369215.5NM_021620.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Macular Dystrophies

    • North Carolina Macular DystrophyAutosomal dominant

      A dominant, largely non-progressive macular dystrophy present from early life, associated with changes near the PRDM13 gene.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How PRDM13 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 6, with a bracket where PRDM13 sits. PRDM13 and 6 genes near it on chromosome 6, from 99,111,198 to 100,111,197.Chromosome 66q16.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2799.2 Mb99.4 Mb99.6 Mb99.8 Mb100 MbFAXC: 99,271,168–99,350,062, reverse strandFAXCCOQ3: 99,369,401–99,394,211, reverse strandCOQ3PNISR: 99,397,629–99,425,963, reverse strandPNISRUSP45: 99,432,325–99,521,728, reverse strandUSP45CCNC: 99,530,630–99,568,825, reverse strandCCNCPRDM13: 99,606,833–99,615,562, forward strandPRDM13MCHR2: 99,918,501–99,994,247, reverse strandMCHR2Diagram of PRDM13: 4 exons on the forward strand of chromosome 6Exon 4: 2 known disease-causing sitesExon 1: 99,606,833–99,607,178, 346 basesExon 2: 99,608,741–99,608,872, 132 basesExon 3: 99,609,187–99,609,307, 121 basesExon 4: 99,613,033–99,615,562, 2,530 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 8.7 kb; 2,124 of those bases code for the protein.

How a genome test reads PRDM13

2

positions in PRDM13 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.7 kb of PRDM13, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRDM13 gene: PR/SET domain 13. Retrieved 17 October 2026, from https://dantelabs.com/genes/prdm13

Vancouver

Dante Labs. PRDM13 gene: PR/SET domain 13 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/prdm13

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