Traits

Traits linked to PPARG

peroxisome proliferator activated receptor gamma

The Human Phenotype Ontology links 46 traits to PPARG, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Body fails to respond to insulin	Always
Hyperinsulinemia	Always
Increased plasma triglycerides	Always
Noninsulin-dependent diabetes	Always
Diabetes mellitus	Very often (80–99%)
Insulin resistant diabetes	Very often (80–99%)
Decreased circulating high-density lipoprotein cholesterol	Often (30–79%)
High blood sugar	Often (30–79%)
Fatty infiltration of liver	Sometimes (5–29%)
High blood uric acid level	Sometimes (5–29%)
Decreased resting energy expenditure	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Always
Narrowing and hardening of arteries	Often (30–79%)
Cardiac failure	Sometimes (5–29%)
Enlarged and thickened heart muscle	Sometimes (5–29%)
Increased spleen size	Sometimes (5–29%)
Plaque build-up in arteries supplying blood to heart	Sometimes (5–29%)
Prominent veins on trunk	Rarely (1–4%)
Prominent veins	Not recorded

Abnormality of the integument

Trait	How often it is seen
Absent/small skin	Very often (80–99%)
Yellow bumps of fatty deposits on skin	Very often (80–99%)
Darkened and thickened skin	Often (30–79%)
Thin skin	Often (30–79%)
Excessive hairiness over body	Sometimes (5–29%)
Excessive hairiness	Not recorded
Reduced fat tissue below the skin	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Inability to make and keep healthy fat tissue	Always
Loss of fat tissue in localized area	Always
Loss of fat tissue below the skin in limbs	Very often (80–99%)
Increased skeletal muscle cells	Often (30–79%)
Abnormality of skeletal muscle fiber size	Sometimes (5–29%)
Muscle tissue disease	Sometimes (5–29%)
Loss of fat tissue below the skin in gluts	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Light or infrequent menstrual periods	Often (30–79%)
Previous menstrual periods stop	Often (30–79%)
Primary amenorrhea	Often (30–79%)
Painful menstruation	Sometimes (5–29%)
Polycystic ovaries	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Very often (80–99%)
Pancreatic inflammation	Sometimes (5–29%)
Scar tissue replaces healthy tissue in the liver	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Increased waist to hip ratio	Not recorded
Obesity	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Decreased amount of facial fat	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Calf muscle pseudohypertrophy	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Muscle ache	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PPARG and how often each is seen. Find out more at hpo.jax.org.

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