Traits

Traits linked to NARS1

asparaginyl-tRNA synthetase 1

The Human Phenotype Ontology links 44 traits to NARS1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Ataxia	Always
Delayed ability to walk	Always
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability	Always
Delayed ability to sit	Very often (80–99%)
Bilateral tonic-clonic seizure with generalized onset	Often (30–79%)
Decreased reflex response	Often (30–79%)
Impaired touch sensation	Often (30–79%)
Inability to coordinate movements when walking	Often (30–79%)
Increased reflexes	Often (30–79%)
Peripheral neuropathy	Often (30–79%)
Seizure affecting one half of brain	Often (30–79%)
Brain degeneration	Sometimes (5–29%)
Cerebral white matter hypoplasia	Sometimes (5–29%)
Delayed CNS myelination	Sometimes (5–29%)
Fewer and broader ridges in brain	Sometimes (5–29%)
Fluid-filled sac located in membrane surrounding brain or spinal cord	Sometimes (5–29%)
Jerking	Sometimes (5–29%)
Myoclonic seizure	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)
Tremor	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)
Widened cerebral subarachnoid space	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Often (30–79%)
Spasticity and rigidity of muscles	Often (30–79%)
Funnel chest	Sometimes (5–29%)
Thoracic kyphosis	Sometimes (5–29%)
Flexed joint that cannot be straightened	Rarely (1–4%)
Scoliosis	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Upward slanting of the opening between the eyelids	Often (30–79%)
Broad forehead	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Widely spaced teeth	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of digit	Sometimes (5–29%)
High-arched foot	Sometimes (5–29%)
Long slender fingers	Sometimes (5–29%)
Webbed fingers or toes	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Large fleshy ears	Sometimes (5–29%)
Low-set ears	Sometimes (5–29%)
Overfolded ears	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Sometimes (5–29%)
Abnormally close eyes	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NARS1 and how often each is seen. Find out more at hpo.jax.org.

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