Traits

Traits linked to LIN28B

lin-28 RNA binding posttranscriptional regulator B

The Human Phenotype Ontology links 34 traits to LIN28B, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Cancer of early nerve cells	Very often (80–99%)
Nervous system cancer	Very often (80–99%)
Antalgic gait	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Pressure on spinal cord	Sometimes (5–29%)
Ataxia	Rarely (1–4%)
Jerking	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Elevated urinary catecholamines	Very often (80–99%)
Fever	Often (30–79%)
Elevated serum ferritin	Sometimes (5–29%)
Elevated urinary homovanillic acid	Sometimes (5–29%)
Elevated urinary vanillylmandelic acid	Sometimes (5–29%)
Increased circulating lactate dehydrogenase concentration	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Often (30–79%)
Low platelet count	Often (30–79%)
Abnormality of coagulation	Sometimes (5–29%)
Bleeding tendency	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal bloating	Often (30–79%)
Abdominal mass	Often (30–79%)
Chronic diarrhea	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Bulging eye	Sometimes (5–29%)
Horner syndrome	Sometimes (5–29%)
Opsoclonus	Rarely (1–4%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes	Often (30–79%)
High blood pressure	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Anemic pallor	Sometimes (5–29%)
Firm lump under the skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bone pain	Sometimes (5–29%)
Spontaneous fracture	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Raccoon eyes	Rarely (1–4%)

Abnormality of the endocrine system

Trait	How often it is seen
Elevated circulating catecholamine level	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Weight loss	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LIN28B and how often each is seen. Find out more at hpo.jax.org.

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