Traits

Traits linked to IL1RN

interleukin 1 receptor antagonist

The Human Phenotype Ontology links 27 traits to IL1RN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Broad ribs	Always
Flaring of rib cage	Always
Osteopenia	Always
Breakdown of bone	Very often (80–99%)
Fused neck	Often (30–79%)
Periostitis	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Abscess	Always
Bone infection	Always
Pimple	Always
Skin rash	Always

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always
High ESR	Always
Joint swelling	Always
Increased level of L-fucose in urine	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Not recorded
Stomach cancer	Not recorded

Abnormality of the integument

Trait	How often it is seen
Hyperkeratosis	Always
Thickening of upper layer of skin	Always

Abnormality of the respiratory system

Trait	How often it is seen
Pulmonary scarring	Sometimes (5–29%)
Breathing difficulties	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Increased blood neutrophil counts	Always

Abnormality of head or neck

Trait	How often it is seen
Inflammation of the mouth	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Fetal distress	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Motor delay	Always

Constitutional symptom

Trait	How often it is seen
Joint pain	Not recorded

Growth abnormality

Trait	How often it is seen
Faltering weight in infancy	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IL1RN and how often each is seen. Find out more at hpo.jax.org.

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