Traits

Traits linked to DAB1

DAB adaptor protein 1

The Human Phenotype Ontology links 23 traits to DAB1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Ataxia	Always
Difficulty articulating speech	Very often (80–99%)
Falls	Very often (80–99%)
Abnormal gait	Often (30–79%)
Abnormal speech pattern	Often (30–79%)
Cerebellar vermis atrophy	Often (30–79%)
Difficulty performing quick and alternating movements	Often (30–79%)
Diffuse cerebellar atrophy	Often (30–79%)
Explosive speech	Often (30–79%)
Instability or lack of coordination of central trunk muscles	Often (30–79%)
Jerking	Often (30–79%)
Somatic sensory dysfunction	Often (30–79%)
Tremor	Often (30–79%)
Uncoordinated limb movement	Often (30–79%)
Unsteady walk	Often (30–79%)
Degeneration of cerebellum	Not recorded

Abnormality of the eye

Trait	How often it is seen
Abnormal conjugate eye movement	Very often (80–99%)
Horizontal nystagmus	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Cogwheel rigidity	Very often (80–99%)
Frequent falls	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Poor swallowing	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DAB1 and how often each is seen. Find out more at hpo.jax.org.

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