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Gene

AKR1C2

aldo-keto reductase family 1 member C2

Summary

Cytogenetic location
10p15.1
Coordinates
Chromosome 10: 4,987,775–5,003,857 (GRCh38)
Exons
9 exons across 16.1 kb
Protein
323 amino acids
Also known as
DD, BABP, DD2, HAKRD, MCDR2
Previous symbols
DDH2, TDD
MANE Select transcript
ENST00000380753.9NM_001393392.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads AKR1C2 yet. The test sequences your whole genome, so your data includes it all the same.

How AKR1C2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where AKR1C2 sits. AKR1C2 and 8 genes near it on chromosome 10, from 4,495,816 to 5,495,815.Chromosome 1010p15.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.34.6 Mb4.8 Mb5 Mb5.2 Mb5.4 MbAKR1E2: 4,786,629–4,848,062, forward strandAKR1E2AKR1C1: 4,944,110–4,983,283, forward strandAKR1C1AKR1C2: 4,987,775–5,003,857, reverse strandAKR1C2AKR1C3: 5,035,354–5,108,244, forward strandAKR1C3AKR1C8: 5,121,764–5,185,190, reverse strandAKR1C8AKR1C4: 5,195,462–5,220,608, forward strandAKR1C4UCN3: 5,364,966–5,374,692, forward strandUCN3TUBAL3: 5,393,101–5,404,832, reverse strandTUBAL3NET1: 5,412,543–5,459,058, forward strandNET1Diagram of AKR1C2: 9 exons on the reverse strand of chromosome 10Exon 3: 1 known disease-causing siteExon 9: 4,987,775–4,990,038, 2,264 basesExon 8: 4,991,831–4,991,913, 83 basesExon 7: 4,995,319–4,995,484, 166 basesExon 6: 4,995,756–4,995,865, 110 basesExon 5: 4,998,625–4,998,747, 123 basesExon 4: 4,999,200–4,999,277, 78 basesExon 3: 5,000,550–5,000,666, 117 basesExon 2: 5,001,514–5,001,681, 168 basesExon 1: 5,003,752–5,003,857, 106 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 16.1 kb; 972 of those bases code for the protein.

How a genome test reads AKR1C2

1

position in AKR1C2 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 16.1 kb of AKR1C2, introns included, not only the 3.2 kb of exons.

Traits linked to AKR1C2

The Human Phenotype Ontology lists these as features of the rare conditions AKR1C2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AKR1C2 gene: aldo-keto reductase family 1 member C2. Retrieved 17 October 2026, from https://dantelabs.com/genes/akr1c2

Vancouver

Dante Labs. AKR1C2 gene: aldo-keto reductase family 1 member C2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/akr1c2

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