{
  "url": "https://dantelabs.com/traits/widened-subarachnoid-space",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "widened-subarachnoid-space",
    "id": "HP:0012704",
    "name": "Widened subarachnoid space",
    "definition": "An increase in size of the anatomic space between the arachnoid membrane and pia mater.",
    "synonyms": [
      "Enlarged subarachnoid space"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-subarachnoid-space-morphology",
        "name": "Abnormal subarachnoid space morphology",
        "url": "https://dantelabs.com/traits/abnormal-subarachnoid-space-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "widened-cerebral-subarachnoid-space",
        "name": "Widened cerebral subarachnoid space",
        "genes": 19,
        "url": "https://dantelabs.com/traits/widened-cerebral-subarachnoid-space"
      },
      {
        "slug": "widened-cerebellar-subarachnoid-space",
        "name": "Widened cerebellar subarachnoid space",
        "genes": 6,
        "url": "https://dantelabs.com/traits/widened-cerebellar-subarachnoid-space"
      }
    ],
    "genes": [
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "hgnc": "HGNC:13552",
        "name": "ATPase phospholipid transporting 11A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp11a"
      },
      {
        "slug": "dtymk",
        "symbol": "DTYMK",
        "hgnc": "HGNC:3061",
        "name": "deoxythymidylate kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtymk"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "hoxa13",
        "symbol": "HOXA13",
        "hgnc": "HGNC:5102",
        "name": "homeobox A13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa13"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "pigw",
        "symbol": "PIGW",
        "hgnc": "HGNC:23213",
        "name": "phosphatidylinositol glycan anchor biosynthesis class W",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigw"
      },
      {
        "slug": "slc33a1",
        "symbol": "SLC33A1",
        "hgnc": "HGNC:95",
        "name": "solute carrier family 33 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc33a1"
      },
      {
        "slug": "cox16",
        "symbol": "COX16",
        "hgnc": "HGNC:20213",
        "name": "cytochrome c oxidase assembly factor COX16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox16"
      },
      {
        "slug": "dnm1",
        "symbol": "DNM1",
        "hgnc": "HGNC:2972",
        "name": "dynamin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1"
      },
      {
        "slug": "gcdh",
        "symbol": "GCDH",
        "hgnc": "HGNC:4189",
        "name": "glutaryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcdh"
      },
      {
        "slug": "otud7a",
        "symbol": "OTUD7A",
        "hgnc": "HGNC:20718",
        "name": "OTU deubiquitinase 7A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otud7a"
      },
      {
        "slug": "ahcy",
        "symbol": "AHCY",
        "hgnc": "HGNC:343",
        "name": "adenosylhomocysteinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahcy"
      },
      {
        "slug": "aldh7a1",
        "symbol": "ALDH7A1",
        "hgnc": "HGNC:877",
        "name": "aldehyde dehydrogenase 7 family member A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh7a1"
      },
      {
        "slug": "alg11",
        "symbol": "ALG11",
        "hgnc": "HGNC:32456",
        "name": "ALG11 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg11"
      },
      {
        "slug": "alg2",
        "symbol": "ALG2",
        "hgnc": "HGNC:23159",
        "name": "ALG2 alpha-1,3/1,6-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg2"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "cux1",
        "symbol": "CUX1",
        "hgnc": "HGNC:2557",
        "name": "cut like homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cux1"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "grin1",
        "symbol": "GRIN1",
        "hgnc": "HGNC:4584",
        "name": "glutamate ionotropic receptor NMDA type subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin1"
      },
      {
        "slug": "kifbp",
        "symbol": "KIFBP",
        "hgnc": "HGNC:23419",
        "name": "kinesin family binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kifbp"
      },
      {
        "slug": "mpdu1",
        "symbol": "MPDU1",
        "hgnc": "HGNC:7207",
        "name": "mannose-P-dolichol utilization defect 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpdu1"
      },
      {
        "slug": "mtrr",
        "symbol": "MTRR",
        "hgnc": "HGNC:7473",
        "name": "5-methyltetrahydrofolate-homocysteine methyltransferase reductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtrr"
      },
      {
        "slug": "plpbp",
        "symbol": "PLPBP",
        "hgnc": "HGNC:9457",
        "name": "pyridoxal phosphate binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plpbp"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "wac",
        "symbol": "WAC",
        "hgnc": "HGNC:17327",
        "name": "WW domain containing adaptor with coiled-coil",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wac"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      }
    ]
  }
}