{
  "url": "https://dantelabs.com/traits/small-thenar-eminence",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "small-thenar-eminence",
    "id": "HP:0001245",
    "name": "Small thenar eminence",
    "definition": "Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb.",
    "synonyms": [
      "Decreased thenar eminence",
      "Hypoplastic thenar eminences",
      "Thenar hypoplasia",
      "Thenar muscle hypoplasia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-thenar-eminence",
        "name": "Abnormality of the thenar eminence",
        "url": "https://dantelabs.com/traits/abnormality-of-the-thenar-eminence"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dhrs3",
        "symbol": "DHRS3",
        "hgnc": "HGNC:17693",
        "name": "dehydrogenase/reductase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhrs3"
      },
      {
        "slug": "hoxa13",
        "symbol": "HOXA13",
        "hgnc": "HGNC:5102",
        "name": "homeobox A13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa13"
      },
      {
        "slug": "eif4a3",
        "symbol": "EIF4A3",
        "hgnc": "HGNC:18683",
        "name": "eukaryotic translation initiation factor 4A3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eif4a3"
      },
      {
        "slug": "sall4",
        "symbol": "SALL4",
        "hgnc": "HGNC:15924",
        "name": "spalt like transcription factor 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sall4"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "emilin1",
        "symbol": "EMILIN1",
        "hgnc": "HGNC:19880",
        "name": "elastin microfibril interfacer 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emilin1"
      },
      {
        "slug": "fgd4",
        "symbol": "FGD4",
        "hgnc": "HGNC:19125",
        "name": "FYVE, RhoGEF and PH domain containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgd4"
      },
      {
        "slug": "lef1",
        "symbol": "LEF1",
        "hgnc": "HGNC:6551",
        "name": "lymphoid enhancer binding factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lef1"
      },
      {
        "slug": "rad51c",
        "symbol": "RAD51C",
        "hgnc": "HGNC:9820",
        "name": "RAD51 paralog C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51c"
      },
      {
        "slug": "rps19",
        "symbol": "RPS19",
        "hgnc": "HGNC:10402",
        "name": "ribosomal protein S19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps19"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "fbxw11",
        "symbol": "FBXW11",
        "hgnc": "HGNC:13607",
        "name": "F-box and WD repeat domain containing 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxw11"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      }
    ]
  }
}