{
  "url": "https://dantelabs.com/traits/decreased-dlco",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "decreased-dlco",
    "id": "HP:0045051",
    "name": "Decreased DLCO",
    "definition": "Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.",
    "synonyms": [
      "Decreased diffusing capacity"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-dlco",
        "name": "Abnormal DLCO",
        "url": "https://dantelabs.com/traits/abnormal-dlco"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "csf2ra",
        "symbol": "CSF2RA",
        "hgnc": "HGNC:2435",
        "name": "colony stimulating factor 2 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf2ra"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "pot1",
        "symbol": "POT1",
        "hgnc": "HGNC:17284",
        "name": "protection of telomeres 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pot1"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "eif2ak4",
        "symbol": "EIF2AK4",
        "hgnc": "HGNC:19687",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eif2ak4"
      },
      {
        "slug": "abca3",
        "symbol": "ABCA3",
        "hgnc": "HGNC:33",
        "name": "ATP binding cassette subfamily A member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca3"
      },
      {
        "slug": "abcc6",
        "symbol": "ABCC6",
        "hgnc": "HGNC:57",
        "name": "ATP binding cassette subfamily C member 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc6"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "hgnc": "HGNC:13552",
        "name": "ATPase phospholipid transporting 11A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp11a"
      },
      {
        "slug": "dpp9",
        "symbol": "DPP9",
        "hgnc": "HGNC:18648",
        "name": "dipeptidyl peptidase 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp9"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "fam13a",
        "symbol": "FAM13A",
        "hgnc": "HGNC:19367",
        "name": "family with sequence similarity 13 member A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam13a"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "muc5b",
        "symbol": "MUC5B",
        "hgnc": "HGNC:7516",
        "name": "mucin 5B, oligomeric mucus/gel-forming",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/muc5b"
      },
      {
        "slug": "serpina1",
        "symbol": "SERPINA1",
        "hgnc": "HGNC:8941",
        "name": "serpin family A member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpina1"
      },
      {
        "slug": "sftpa1",
        "symbol": "SFTPA1",
        "hgnc": "HGNC:10798",
        "name": "surfactant protein A1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sftpa1"
      },
      {
        "slug": "sftpa2",
        "symbol": "SFTPA2",
        "hgnc": "HGNC:10799",
        "name": "surfactant protein A2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sftpa2"
      },
      {
        "slug": "sftpc",
        "symbol": "SFTPC",
        "hgnc": "HGNC:10802",
        "name": "surfactant protein C",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sftpc"
      },
      {
        "slug": "smpd1",
        "symbol": "SMPD1",
        "hgnc": "HGNC:11120",
        "name": "sphingomyelin phosphodiesterase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smpd1"
      },
      {
        "slug": "sox17",
        "symbol": "SOX17",
        "hgnc": "HGNC:18122",
        "name": "SRY-box transcription factor 17",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox17"
      },
      {
        "slug": "stn1",
        "symbol": "STN1",
        "hgnc": "HGNC:26200",
        "name": "STN1 subunit of CST complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stn1"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "xylt2",
        "symbol": "XYLT2",
        "hgnc": "HGNC:15517",
        "name": "xylosyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt2"
      },
      {
        "slug": "copa",
        "symbol": "COPA",
        "hgnc": "HGNC:2230",
        "name": "coat protein complex I subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copa"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf6"
      }
    ]
  }
}