{
  "url": "https://dantelabs.com/traits/chronic-infection",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "chronic-infection",
    "id": "HP:0031035",
    "name": "Chronic infection",
    "definition": "Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "unusual-infection",
        "name": "Unusual infection",
        "url": "https://dantelabs.com/traits/unusual-infection"
      }
    ],
    "narrower": [
      {
        "slug": "chronic-active-ebv-infection",
        "name": "Chronic active EBV infection",
        "genes": 4,
        "url": "https://dantelabs.com/traits/chronic-active-ebv-infection"
      },
      {
        "slug": "chronic-tinea-infection",
        "name": "Chronic tinea infection",
        "genes": 3,
        "url": "https://dantelabs.com/traits/chronic-tinea-infection"
      }
    ],
    "genes": [
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "fip1l1",
        "symbol": "FIP1L1",
        "hgnc": "HGNC:19124",
        "name": "factor interacting with PAPOLA and CPSF1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fip1l1"
      },
      {
        "slug": "irf2bp2",
        "symbol": "IRF2BP2",
        "hgnc": "HGNC:21729",
        "name": "interferon regulatory factor 2 binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf2bp2"
      },
      {
        "slug": "nabp1",
        "symbol": "NABP1",
        "hgnc": "HGNC:26232",
        "name": "nucleic acid binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nabp1"
      },
      {
        "slug": "npm1",
        "symbol": "NPM1",
        "hgnc": "HGNC:7910",
        "name": "nucleophosmin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npm1"
      },
      {
        "slug": "numa1",
        "symbol": "NUMA1",
        "hgnc": "HGNC:8059",
        "name": "nuclear mitotic apparatus protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/numa1"
      },
      {
        "slug": "pml",
        "symbol": "PML",
        "hgnc": "HGNC:9113",
        "name": "PML nuclear body scaffold",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pml"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rara",
        "symbol": "RARA",
        "hgnc": "HGNC:9864",
        "name": "retinoic acid receptor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rara"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "stat5b",
        "symbol": "STAT5B",
        "hgnc": "HGNC:11367",
        "name": "signal transducer and activator of transcription 5B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat5b"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "zbtb16",
        "symbol": "ZBTB16",
        "hgnc": "HGNC:12930",
        "name": "zinc finger and BTB domain containing 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb16"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "rps14",
        "symbol": "RPS14",
        "hgnc": "HGNC:10387",
        "name": "ribosomal protein S14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps14"
      },
      {
        "slug": "sf3b1",
        "symbol": "SF3B1",
        "hgnc": "HGNC:10768",
        "name": "splicing factor 3b subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sf3b1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "bche",
        "symbol": "BCHE",
        "hgnc": "HGNC:983",
        "name": "butyrylcholinesterase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bche"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "plekhm1",
        "symbol": "PLEKHM1",
        "hgnc": "HGNC:29017",
        "name": "pleckstrin homology and RUN domain containing M1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhm1"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      }
    ]
  }
}