{
  "url": "https://dantelabs.com/traits/acantholysis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "acantholysis",
    "id": "HP:0100792",
    "name": "Acantholysis",
    "definition": "The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-epidermal-morphology",
        "name": "Abnormal epidermal morphology",
        "url": "https://dantelabs.com/traits/abnormal-epidermal-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cast",
        "symbol": "CAST",
        "hgnc": "HGNC:1515",
        "name": "calpastatin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cast"
      },
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "hgnc": "HGNC:3048",
        "name": "desmoglein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsg1"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jup"
      },
      {
        "slug": "tuft1",
        "symbol": "TUFT1",
        "hgnc": "HGNC:12422",
        "name": "tuftelin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuft1"
      },
      {
        "slug": "atp2c1",
        "symbol": "ATP2C1",
        "hgnc": "HGNC:13211",
        "name": "ATPase secretory pathway Ca2+ transporting 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2c1"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "ikzf1",
        "symbol": "IKZF1",
        "hgnc": "HGNC:13176",
        "name": "IKAROS family zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf1"
      },
      {
        "slug": "krt2",
        "symbol": "KRT2",
        "hgnc": "HGNC:6439",
        "name": "keratin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt2"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp2a2"
      }
    ]
  }
}