{
  "url": "https://dantelabs.com/traits/abnormal-upper-motor-neuron-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-upper-motor-neuron-morphology",
    "id": "HP:0002127",
    "name": "Abnormal shape of upper motor neuron",
    "label": "Abnormal upper motor neuron morphology",
    "definition": "Any structural anomaly that affects the upper motor neuron.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-motor-neuron-morphology",
        "name": "Abnormal shape of motor neuron",
        "url": "https://dantelabs.com/traits/abnormal-motor-neuron-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "als2",
        "symbol": "ALS2",
        "hgnc": "HGNC:443",
        "name": "alsin Rho guanine nucleotide exchange factor ALS2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/als2"
      },
      {
        "slug": "chchd10",
        "symbol": "CHCHD10",
        "hgnc": "HGNC:15559",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chchd10"
      },
      {
        "slug": "erlin2",
        "symbol": "ERLIN2",
        "hgnc": "HGNC:1356",
        "name": "ER lipid raft associated 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erlin2"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "tardbp",
        "symbol": "TARDBP",
        "hgnc": "HGNC:11571",
        "name": "TAR DNA binding protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tardbp"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "pnpla6",
        "symbol": "PNPLA6",
        "hgnc": "HGNC:16268",
        "name": "patatin like domain 6, lysophospholipase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpla6"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "gbe1",
        "symbol": "GBE1",
        "hgnc": "HGNC:4180",
        "name": "1,4-alpha-glucan branching enzyme 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gbe1"
      },
      {
        "slug": "matr3",
        "symbol": "MATR3",
        "hgnc": "HGNC:6912",
        "name": "matrin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matr3"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "tyrobp",
        "symbol": "TYROBP",
        "hgnc": "HGNC:12449",
        "name": "transmembrane immune signaling adaptor TYROBP",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrobp"
      }
    ]
  }
}