Traits

Traits linked to ZNF365

zinc finger protein 365

The Human Phenotype Ontology links 32 traits to ZNF365, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Cataplexy	Very often (80–99%)
Difficulty sleeping	Very often (80–99%)
Difficulty staying or falling asleep	Very often (80–99%)
Excessive daytime sleepiness	Very often (80–99%)
Hallucinations	Very often (80–99%)
Transient global amnesia	Very often (80–99%)
Abnormal rapid eye movement sleep	Often (30–79%)
Anxiety	Often (30–79%)
Attention deficit	Often (30–79%)
Hypnagogic hallucination	Often (30–79%)
Hypnopompic hallucination	Often (30–79%)
NREM parasomnia	Often (30–79%)
Willis-Ekbom disease	Often (30–79%)
Behavioral abnormality	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Migraine	Sometimes (5–29%)
Pauses in breathing while sleeping	Sometimes (5–29%)
Restlessness	Sometimes (5–29%)
Sleep paralysis	Sometimes (5–29%)
Slurred speech	Sometimes (5–29%)
Psychosis	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Female sexual dysfunction	Often (30–79%)
Male sexual dysfunction	Often (30–79%)
Nocturia	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Fainting spell	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Drooling	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Early onset of puberty	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormal pupillary function	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Obesity	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZNF365 and how often each is seen. Find out more at hpo.jax.org.

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