Traits

Traits linked to ZNF341

zinc finger protein 341

The Human Phenotype Ontology links 30 traits to ZNF341, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Eczema	Always
Recurrent skin infections	Always
Methicillin-resistant Staphylococcus aureus infection	Often (30–79%)
Sterile abscess	Often (30–79%)
Bone infection	Sometimes (5–29%)
Recurrent pneumonia	Sometimes (5–29%)
Skin abscess	Sometimes (5–29%)
Baby eczema	Not recorded
Recurrent infections	Not recorded
Recurrent mucocutaneous candidiasis	Not recorded
Recurrent respiratory infections	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Chronic oral thrush	Sometimes (5–29%)
Recurrent sinus disease	Sometimes (5–29%)
Abnormal dentition	Not recorded
High palate	Not recorded
Little lower jaw	Not recorded
Wide nose	Not recorded

Abnormality of the integument

Trait	How often it is seen
Dry skin	Sometimes (5–29%)
Hair loss	Rarely (1–4%)
Itching	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgE concentration	Very often (80–99%)
Decreased circulating IgA concentration	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Narrowing of pulmonic valve	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Narrow spinal canal	Sometimes (5–29%)
Double-Jointed	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
High blood eosinophil count	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability, mild	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZNF341 and how often each is seen. Find out more at hpo.jax.org.

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