Traits

Traits linked to SNAI2

snail family transcriptional repressor 2

The Human Phenotype Ontology links 25 traits to SNAI2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
White eyebrow	Often (30–79%)
White eyelashes	Often (30–79%)
Abnormality of cranium	Sometimes (5–29%)
Abnormally small head	Sometimes (5–29%)
Corners of eye widely separated	Sometimes (5–29%)
Long philtrum	Sometimes (5–29%)
Monobrow	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Loss of hair color	Very often (80–99%)
Piebald skin depigmentation	Very often (80–99%)
Premature graying of hair	Very often (80–99%)
White part of hair above forehead	Very often (80–99%)
Flat, discolored area of skin	Often (30–79%)
Patchy loss of skin color	Often (30–79%)
Skin cancer	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Very often (80–99%)
Sensorineural hearing impairment	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Different colored eyes	Often (30–79%)
Drooping upper eyelid	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Ataxia	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormality of lung artery	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged colon lacking nerve cells	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the kidney	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SNAI2 and how often each is seen. Find out more at hpo.jax.org.

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