Traits

Traits linked to OVOL2

ovo like zinc finger 2

The Human Phenotype Ontology links 26 traits to OVOL2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Abnormal Descemet membrane morphology	Very often (80–99%)
Reduced number of corneal endothelial cells	Very often (80–99%)
Anterior synechiae of the anterior chamber	Sometimes (5–29%)
Astigmatism	Sometimes (5–29%)
Decreased clarity of vision	Sometimes (5–29%)
Displaced pupil	Sometimes (5–29%)
Increased corneal curvature	Sometimes (5–29%)
Iris degeneration	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)
Thinning of Descemet membrane	Sometimes (5–29%)
Uveal ectropion	Sometimes (5–29%)
Very low visual acuity	Sometimes (5–29%)
Abnormality of tear production	Rarely (1–4%)
Blurred vision	Rarely (1–4%)
Chorioretinal atrophy	Rarely (1–4%)
Corneal opacity	Rarely (1–4%)
Extreme sensitivity of the eyes to light	Rarely (1–4%)
Eye pain	Rarely (1–4%)
Glaucoma	Rarely (1–4%)
High eye pressure	Rarely (1–4%)
Inward turning cross eyed	Rarely (1–4%)
Abnormal corneal endothelium morphology	Not recorded
Band keratopathy	Not recorded
Increased tears	Not recorded
Polymorphous posterior corneal dystrophy	Not recorded

Laboratory abnormality

Trait	How often it is seen
Corneal stromal edema	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to OVOL2 and how often each is seen. Find out more at hpo.jax.org.

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