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Gene

ONECUT1

one cut homeobox 1

Summary

Cytogenetic location
15q21.3
Coordinates
Chromosome 15: 52,755,053–52,790,336 (GRCh38)
Exons
2 exons across 35.3 kb
Protein
465 amino acids
Also known as
HNF-6
Previous symbols
HNF6, HNF6A
MANE Select transcript
ENST00000305901.7NM_004498.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Neonatal Diabetes Mellitus

    • Diabetes diagnosed in the first months of life, either permanent or transient, caused by single-gene defects in insulin production or secretion.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Most people with KCNJ11 or ABCC8 neonatal diabetes can switch from insulin injections to sulfonylurea tablets, often with better glucose control.

How ONECUT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 15, with a bracket where ONECUT1 sits. ONECUT1 and 4 genes near it on chromosome 15, from 52,272,695 to 53,272,694.Chromosome 1515q21.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.352.4 Mb52.6 Mb52.8 Mb53 Mb53.2 MbMYO5C: 52,192,309–52,295,815, reverse strandMYO5CMYO5A: 52,307,281–52,529,248, reverse strandMYO5AARPP19: 52,547,045–52,569,883, reverse strandARPP19ATOSA: 52,581,317–52,709,824, reverse strandATOSAONECUT1: 52,755,053–52,790,336, reverse strandONECUT1Diagram of ONECUT1: 2 exons on the reverse strand of chromosome 15Exon 2: 52,755,053–52,757,847, 2,795 basesExon 1: 52,788,780–52,790,336, 1,557 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 35.3 kb; 1,398 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ONECUT1 gene: one cut homeobox 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/onecut1

Vancouver

Dante Labs. ONECUT1 gene: one cut homeobox 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/onecut1

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