Traits

Traits linked to OAS2

2'-5'-oligoadenylate synthetase 2

The Human Phenotype Ontology links 26 traits to OAS2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Chronic kidney disease	Always
Glomerular sclerosis	Always
Glomerulonephritis	Always
Hyperechogenic kidneys	Always
Renal interstitial fibrosis	Always
Renal tubular atrophy	Always

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal heart rate	Always
Heart attack	Always
High blood pressure	Always
Inflammation of blood vessel	Always
ST segment elevation	Always

Laboratory abnormality

Trait	How often it is seen
Elevated gamma-glutamyltransferase level	Always
Increased circulating potassium concentration	Always
Metabolic acidosis	Always
Nephrotic range proteinuria	Always
Small amount of blood in urine	Always

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bleeding in brain	Always
Bloody nose	Always
Decreased hemoglobin concentration	Always
Rectal bleeding	Always

Abnormality of the immune system

Trait	How often it is seen
Anti-myeloperoxidase antibody positivity	Always
Antinuclear antibody positivity	Always
Cytokine storm	Always

Abnormality of the nervous system

Trait	How often it is seen
Epilepsy	Always
Weakness of one side of body	Always

Abnormality of the digestive system

Trait	How often it is seen
Bile duct inflammation	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to OAS2 and how often each is seen. Find out more at hpo.jax.org.

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