Traits

Traits linked to NLRP12

NLR family pyrin domain containing 12

The Human Phenotype Ontology links 18 traits to NLRP12, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Hives	Very often (80–99%)
Increased spleen size	Often (30–79%)
Swollen lymph nodes	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always
Episodic fever	Always
High ESR	Always

Abnormality of the immune system

Trait	How often it is seen
Erythema nodosum	Often (30–79%)
Skin rash	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Lower limb pain	Often (30–79%)
Arthritis	Not recorded

Constitutional symptom

Trait	How often it is seen
Joint pain	Very often (80–99%)
Muscle ache	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Elevated white blood count	Always

Abnormality of head or neck

Trait	How often it is seen
Recurrent canker sores	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Not recorded

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Headache	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Sore throat	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NLRP12 and how often each is seen. Find out more at hpo.jax.org.

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