Traits

Traits linked to NECTIN4

nectin cell adhesion molecule 4

The Human Phenotype Ontology links 19 traits to NECTIN4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Flattened and twisted hair	Always
Hair loss	Always
Absent facial hair	Not recorded
Coarse hair	Not recorded
Ectodermal dysplasia	Not recorded
Patchy baldness	Not recorded
Small nail	Not recorded
Underdeveloped toenails	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Cone shaped tooth	Not recorded
Sparse eyelashes	Not recorded
Sparse scalp hair	Not recorded
Thin dental enamel	Not recorded
Widely spaced teeth	Not recorded

Abnormality of limbs

Trait	How often it is seen
Webbed skin of 2nd-3rd toes	Always
Webbed 4th-5th toes	Often (30–79%)
Webbed index through ring fingers	Often (30–79%)
Palmar hyperkeratosis	Not recorded
Webbed fingers	Not recorded

Laboratory abnormality

Trait	How often it is seen
Heat intolerance	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NECTIN4 and how often each is seen. Find out more at hpo.jax.org.

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