Traits

Traits linked to KCNE1

potassium voltage-gated channel subfamily E regulatory subunit 1

The Human Phenotype Ontology links 26 traits to KCNE1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Extra heart beat	Always
Fainting spell	Always
Prolonged QT interval	Always
Sinus bradycardia	Always
Prolonged QTc interval	Very often (80–99%)
Abnormal heart rate	Often (30–79%)
Palpitations	Often (30–79%)
Quivering upper heart chambers resulting in irregular heartbeat	Often (30–79%)
Torsade de pointes	Often (30–79%)
Ventricular fibrillation	Often (30–79%)
Heart attack	Sometimes (5–29%)
Sudden cardiac death	Not recorded

Abnormality of the ear

Trait	How often it is seen
Congenital sensorineural hearing impairment	Always
Bilateral sensorineural hearing impairment	Very often (80–99%)
Profound sensorineural hearing impairment	Very often (80–99%)
Dizziness	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Chest pain	Often (30–79%)
Decreased ability to exercise	Often (30–79%)
Fatigue	Often (30–79%)
Postexertional symptom exacerbation	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Iron deficiency anemia	Sometimes (5–29%)
Thromboembolic stroke	Sometimes (5–29%)
Thromboembolism	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Loss of consciousness	Often (30–79%)
Epilepsy	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulty	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KCNE1 and how often each is seen. Find out more at hpo.jax.org.

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