Traits

Traits linked to ITGB3

integrin subunit beta 3

The Human Phenotype Ontology links 43 traits to ITGB3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormally heavy bleeding during menstruation	Always
Bleeding tendency	Always
Bruising susceptibility	Always
Impaired ADP-induced platelet aggregation	Always
Impaired arachidonic acid-induced platelet aggregation	Always
Impaired collagen-induced platelet aggregation	Always
Impaired epinephrine-induced platelet aggregation	Always
Large platelets	Always
Low platelet count	Always
Neonatal alloimmune thrombocytopenia	Always
Platelet anisocytosis	Always
Impaired clot retraction	Very often (80–99%)
Macrothrombocytopenia	Very often (80–99%)
Prolonged bleeding time	Very often (80–99%)
Recurring nosebleed	Very often (80–99%)
Bleeding gums	Often (30–79%)
Blood spots	Often (30–79%)
Cephalohematoma	Often (30–79%)
Decreased platelet glycoprotein IIb-IIIa	Often (30–79%)
Petechiae	Often (30–79%)
Prolonged bleeding after surgery	Often (30–79%)
Prolonged bleeding following circumcision	Often (30–79%)
Spontaneous hematomas	Often (30–79%)
Black feces	Sometimes (5–29%)
Bleeding within the skull	Sometimes (5–29%)
Bloody nose	Sometimes (5–29%)
Ecchymosis	Sometimes (5–29%)
Gastrointestinal bleeding	Sometimes (5–29%)
Prolonged bleeding after dental extraction	Sometimes (5–29%)
Impaired ristocetin-induced platelet aggregation	Rarely (1–4%)
Subarachnoid hemorrhage	Rarely (1–4%)
Impaired collagen-related peptide-induced platelet aggregation	Not recorded
Impaired thrombin-induced platelet aggregation	Not recorded
Impaired thromboxane A2 agonist-induced platelet aggregation	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Rarely (1–4%)
Cerebral palsy	Rarely (1–4%)
Global developmental delay	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal uterus bleeding	Sometimes (5–29%)
Menometrorrhagia	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Sometimes (5–29%)
Bloody urine	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Bilateral sensorineural hearing impairment	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Blindness	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ITGB3 and how often each is seen. Find out more at hpo.jax.org.

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