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Trait

Recurring nosebleed

Clinical name: Spontaneous, recurrent epistaxis

HPO HP:0004406

Summary

Also called
Spontaneous, recurrent nosebleed, Recurrent epistaxes, Recurrent epistaxis
Body system
Abnormality of blood and blood-forming tissuesAbnormality of head or neck

19 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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18 genes linked to Recurring nosebleed

Changes in these genes cause rare conditions in which Recurring nosebleed is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ACVRL1activin A receptor like type 1AlwaysIn 2 conditions
DHRS3dehydrogenase/reductase 3AlwaysIn 1 condition
ENGendoglinAlwaysIn 2 conditions
GDF2growth differentiation factor 2AlwaysIn 2 conditions
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseAlwaysIn 1 condition
HPS3HPS3 biogenesis of lysosomal organelles complex 2 subunit 1AlwaysIn 1 condition
ITGA2Bintegrin subunit alpha 2bVery often (80–99%)In 1 condition
ITGB3integrin subunit beta 3Very often (80–99%)In 1 condition
SMAD4SMAD family member 4Very often (80–99%)In 1 condition
GP1BAglycoprotein Ib platelet subunit alphaOften (30–79%)In 1 condition
GP1BBglycoprotein Ib platelet subunit betaOften (30–79%)In 1 condition
GP9glycoprotein IX plateletOften (30–79%)In 1 condition
MYH9myosin heavy chain 9Often (30–79%)In 1 condition
PTPRJprotein tyrosine phosphatase receptor type JOften (30–79%)In 1 condition
TPM4tropomyosin 4Often (30–79%)In 1 condition
GBA1glucosylceramidase beta 1Sometimes (5–29%)In 1 condition
LYSTlysosomal trafficking regulatorNot recordedIn 1 condition
SRCSRC proto-oncogene, non-receptor tyrosine kinaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Bloody nose

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.21-777c9289.

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