Trait

Increased red cell sickling tendency

Also called: Increased sickling of erythrocytes, Increased sickling of red cells
Body system: Abnormality of blood and blood-forming tissues

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5 genes linked to Increased red cell sickling tendency

Changes in these genes cause rare conditions in which Increased red cell sickling tendency is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
BCL11ABCL11 transcription factor A	Sometimes (5–29%)	In 1 condition
HBBhemoglobin subunit beta	Sometimes (5–29%)	In 2 conditions
HBG1hemoglobin subunit gamma 1	Sometimes (5–29%)	In 1 condition
HBG2hemoglobin subunit gamma 2	Sometimes (5–29%)	In 1 condition
KLF1KLF transcription factor 1	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Anemia due to reduced life span of red cells

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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