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Gene

DCT

dopachrome tautomerase

Summary

Cytogenetic location
13q32.1
Coordinates
Chromosome 13: 94,436,811–94,479,682 (GRCh38)
Exons
8 exons across 42.9 kb
Protein
519 amino acids
Inheritance
Autosomal recessive
Also known as
TRP-2, TRP2
Previous symbols
TYRP2
MANE Select transcript
ENST00000377028.10NM_001922.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How DCT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 13, with a bracket where DCT sits. DCT and 4 genes near it on chromosome 13, from 93,958,247 to 94,958,246.Chromosome 1313q32.1p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3494 Mb94.2 Mb94.4 Mb94.6 Mb94.8 MbGPC6: 93,226,807–94,408,020, forward strandGPC6DCT: 94,436,811–94,479,682, reverse strandDCTTGDS: 94,574,041–94,596,286, reverse strandTGDSGPR180: 94,601,788–94,653,091, forward strandGPR180SOX21: 94,709,622–94,712,545, reverse strandSOX21Diagram of DCT: 8 exons on the reverse strand of chromosome 13Exon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 8: 94,436,811–94,440,076, 3,266 basesExon 7: 94,443,436–94,443,637, 202 basesExon 6: 94,460,091–94,460,226, 136 basesExon 5: 94,462,010–94,462,189, 180 basesExon 4: 94,465,633–94,465,799, 167 basesExon 3: 94,466,558–94,466,658, 101 basesExon 2: 94,468,746–94,469,045, 300 basesExon 1: 94,478,961–94,479,682, 722 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 42.9 kb; 1,560 of those bases code for the protein.

How a genome test reads DCT

4

positions in DCT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 42.9 kb of DCT, introns included, not only the 5.1 kb of exons.

Genes linked to the same conditions

Traits linked to DCT

The Human Phenotype Ontology lists these as features of the rare conditions DCT can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DCT gene: dopachrome tautomerase. Retrieved 17 October 2026, from https://dantelabs.com/genes/dct

Vancouver

Dante Labs. DCT gene: dopachrome tautomerase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dct

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