Traits

Traits linked to CORIN

corin, serine peptidase

The Human Phenotype Ontology links 33 traits to CORIN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Always
Left atrial enlargement	Always
Left atrial fibrosis	Always
Elevated diastolic blood pressure	Very often (80–99%)
Elevated systolic blood pressure	Very often (80–99%)
Atrial flutter	Often (30–79%)
Quivering upper heart chambers resulting in irregular heartbeat	Often (30–79%)
Abnormality of liver blood vessels	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Decreased circulating NT-proANP concentration	Always
Increased circulating brain natriuretic peptide concentration	Always
High urine protein levels	Very often (80–99%)
Excess fluid in lungs	Often (30–79%)
High liver enzymes	Sometimes (5–29%)
Elevated creatinine	Rarely (1–4%)
Type 1 diabetes	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Renal failure	Often (30–79%)
Abnormality of the kidney	Sometimes (5–29%)
Acute kidney injury	Rarely (1–4%)
Chronic kidney disease	Rarely (1–4%)
Polycystic ovaries	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Sometimes (5–29%)
Headache	Sometimes (5–29%)
Difficulty sleeping	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Increased body mass index	Sometimes (5–29%)
Prenatal growth deficiency	Sometimes (5–29%)
Small for gestational age	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Helicobacter pylori infection	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low platelet count	Rarely (1–4%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Placental issue	Very often (80–99%)

Abnormality of the eye

Trait	How often it is seen
Abnormality of vision	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Autoimmunity	Rarely (1–4%)

Constitutional symptom

Trait	How often it is seen
Epigastric pain	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CORIN and how often each is seen. Find out more at hpo.jax.org.

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