Traits

Traits linked to APOA4

apolipoprotein A4

The Human Phenotype Ontology links 12 traits to APOA4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal Bowman capsule morphology	Always
Chronic kidney disease	Always
Decreased glomerular filtration rate	Always
Glomerular sclerosis	Always
Stage 5 chronic kidney disease	Always
Renal tubular atrophy	Very often (80–99%)
Glomerular basement membrane wrinkling	Often (30–79%)
Renal interstitial fibrosis	Often (30–79%)
Renal interstitial inflammation	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Gout	Always

Laboratory abnormality

Trait	How often it is seen
Elevated serum cholesterol	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to APOA4 and how often each is seen. Find out more at hpo.jax.org.

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