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Risk score · Cancer

Pancreatic Cancer Polygenic Risk Score

Pancreatic ductal adenocarcinoma is the most common pancreatic cancer. It is uncommon but often found late; smoking, diabetes and family history raise risk.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Pancreatic ductal adenocarcinoma

Genetic variants

49

Method

Curated variants associated with pancreatic cancer

Built from studies of

European 99%, East Asian 1%

Evaluated in

Not reported 100%

Published

Sharma S et al. (2022). Predicting Pancreatic Cancer in the UK Biobank Cohort Using Polygenic Risk Scores and Diabetes Mellitus. Gastroenterology.

The score in the PGS Catalog →

References

  1. Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, 2018. Prediction model for pancreatic cancer risk in the general Japanese population. PLoS One
  2. Molina-Montes E, Coscia C, Gómez-Rubio P, Fernández A, Boenink R, Rava M, 2021. Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. Gut
  3. Galeotti AA, Gentiluomo M, Rizzato C, Obazee O, Neoptolemos JP, Pasquali C, 2021. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. J Med Genet
  4. Jia G, Lu Y, Wen W, Long J, Liu Y, Tao R, 2020. Evaluating the Utility of Polygenic Risk Scores in Identifying High-Risk Individuals for Eight Common Cancers. JNCI Cancer Spectr
  5. Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, 2020. Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nat Commun

Other cancer risk scores

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