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Risk score · Cancer

Prostate Cancer Polygenic Risk Score

Prostate cancer is the most commonly diagnosed cancer in men in many countries. This score combines 269 variants found in a multi-ancestry study of over 200,000 men.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Prostate cancer

Genetic variants

269

Method

Independent genome-wide significant variants identified by fine-mapping using JAM (Joint Analysis of Marginal summary statistics)

Built from studies of

European 76%, East Asian 12%, African 9%, Hispanic or Latin American 3%

Evaluated in

European 47%, Multi-ancestry 26%, African 21%, East Asian 5%

Published

Conti DV et al. (2021). Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet.

The score in the PGS Catalog →

Other cancer risk scores

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

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Free shipping · Results in 6–8 weeks

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