{
  "url": "https://dantelabs.com/traits/venous-insufficiency",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "venous-insufficiency",
    "id": "HP:0005293",
    "name": "Poorly functioning veins",
    "label": "Venous insufficiency",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-venous-morphology",
        "name": "Abnormal vein",
        "url": "https://dantelabs.com/traits/abnormal-venous-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "varicose-veins",
        "name": "Varicose veins",
        "genes": 31,
        "url": "https://dantelabs.com/traits/varicose-veins"
      }
    ],
    "genes": [
      {
        "slug": "thbs2",
        "symbol": "THBS2",
        "hgnc": "HGNC:11786",
        "name": "thrombospondin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbs2"
      },
      {
        "slug": "aggf1",
        "symbol": "AGGF1",
        "hgnc": "HGNC:24684",
        "name": "angiogenic factor with G-patch and FHA domains 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aggf1"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "ndp",
        "symbol": "NDP",
        "hgnc": "HGNC:7678",
        "name": "norrin cystine knot growth factor NDP",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndp"
      },
      {
        "slug": "gjc2",
        "symbol": "GJC2",
        "hgnc": "HGNC:17494",
        "name": "gap junction protein gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjc2"
      },
      {
        "slug": "gnaq",
        "symbol": "GNAQ",
        "hgnc": "HGNC:4390",
        "name": "G protein subunit alpha q",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnaq"
      },
      {
        "slug": "proc",
        "symbol": "PROC",
        "hgnc": "HGNC:9451",
        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/proc"
      },
      {
        "slug": "pros1",
        "symbol": "PROS1",
        "hgnc": "HGNC:9456",
        "name": "protein S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pros1"
      },
      {
        "slug": "smoc1",
        "symbol": "SMOC1",
        "hgnc": "HGNC:20318",
        "name": "SPARC related modular calcium binding 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smoc1"
      }
    ]
  }
}