Trait
Increased bone density in skeletal bones
Clinical name: Generalized osteosclerosis
An abnormal increase of bone mineral density with generalized involvement of the skeleton.
Summary
- Also called
- Diffuse, symmetrical osteosclerosis, Generalised osteosclerosis, Osteosclerosis, diffuse symmetrical
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Read the genes linked to Increased bone density in skeletal bones, and the rest of your genome, with one test.
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Get my Genome Test9 genes linked to Increased bone density in skeletal bones
Changes in these genes cause rare conditions in which Increased bone density in skeletal bones is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 3 conditions |
| LRP5LDL receptor related protein 5 | Very often (80–99%) | In 3 conditions |
| SOSTsclerostin | Very often (80–99%) | In 1 condition |
| CTSKcathepsin K | Often (30–79%) | In 1 condition |
| DHCR2424-dehydrocholesterol reductase | Often (30–79%) | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Often (30–79%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Often (30–79%) | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Rarely (1–4%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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